Fluorescence Cancer Detection, Biomarkers and FNA Portal

Sample Technology Commercialization Support Portal
by Polson Enterprises

Sample Number 1
Fluorescence Cancer Detection, Biomarkers and FNA Portal

We develop Portals of the nature of the one below to assist firms developing specific technologies. This one was developed a few years ago to support a firm developing medical devices and processes. Their specific field of interest was in detecting cancer at an early state using fluorescence. Our Portal provided their development team easy access to the existing knowledge in this field and in competing methods. It also provided them quick access to new information as it became available. The version below is no longer current and many of the links are broken. It is only provided here as an example of our ability to construct Technology Commercialization Support Portals. We can host Portals online or supply code for posting them on your Intranet. Depending on your needs, we can also update them as new information becomes available and as your project begin to focus on more specific areas. Please visit our Polson Enterprises web site for more information about our capabilities.
The example below is presented exactly as we originally supplied it.
Gary Polson
Polson Enterprises

Fluorescence Cancer Detection, Biomarkers and FNA Links

Major Research Efforts in this Field

Patents can be viewed at: U.S. Patent Office, IBM Patent Index, Canadian Patent Office, European Patent Office

Advanced Cytometrix, Inc (Sunnyvale CA) sold to Oncotech (Irvine CA). They are working on cellular predictive changes and a vacuum canister FNA Device. Trevor Powles of the UK is a major researcher for this group. Patents:
- U.S. 5,653,694 text and images (text only copy) Aspiration Needle Apparatus (pulsating vacuum, vibrating needle, saline solution)
- U.S. 5,645,537 Aspiration Needle and Syringe
- U.S. 5,330,443 Aspiration Needle Syringe
- WO 96/32146 Aspiration Needle and Method
- WO 96/32147 Aspiration Needle Apparatus
- WO 99/13928 Aspiration Needle Apparatus
Diagnocure of Quebec Canada is doing research in the area of immuno fluorescence and bladder cancer. Their Immuno Cyt test is currently available. Fradet is a major researcher for them.
- WO 98/12564 Immunological Composition for Detection of Bladder Cancer
- WO 98/12227 Recombinant Single Chain Antibodies Directed Against the GP54 Cancer Marker
- U.S. 5,039,611 Monoclonal Antibodies to Superficial Papillary Bladder Tumor Cells
Cancer Imaging, British Columbia Cancer Agency / Branco Palcic working with Oncometrics Imaging Corp (Vancouver CA) and Xillix Technologies Corp (Richmond B.C. Canada). Xillix liscensed the endoscope to Olympus Optico Co. Ltd. of Tokyo. Xillix also partially owns Oncometrics Imaging. Patents:
- Canadian Patent 2,086,786 Trainable Automatic Imaging Device
- U.S. 5,889,881 text and images (text only copy) Method and Apparatus for sensing MAC (Malignance Associated Changes)
- U.S. 5,827,190 Endoscope w/integrated CCD sensor
- U.S. 5,769,792 Endoscope imaging system
- U.S. 5,590,660 Autofluorescence imaging device
- Also see his patent page for info on patents still in the system.
Ventana Medical Systems working with biomarkers and FISH.
Geron working with Telomerase as a marker
- U.S. 5,891,639 Telomerase activity assays
- U.S. 5,863,726 Telomerase activity assays
- U.S. 5,837,453 Telomerase activity assays
- U.S. 5, 629,154 Telomerase activity assays
MAC (Malignancy Associated Changes) Home Page
Purdue Photon Migration Lab / Eva Sevick-Muraca / Dilip Paithankar. Patents:
- U.S. 5,865,754 Fluorescence imaging system and method (measure lifetime of the fluorescence)
University of Oklahoma / PrevCor / George Hemstreet working on cellular predictive changes, FNA biopsy gun with a replaceable card and automated flourescense image analysis device. Patents:
- U.S. 4,982,739 Biopsy Aspirator
- U.S. 5,081,999 Biopsy Aspirator (method patent)
- U.S. 5,387,191 Flushing Needle
- U.S. 5,669,394 Biopsy Aspirator (replaceable card)
- U.S. 5,380,289 Fluid Collection Device
- U.S. 5,599,331 Fluid Collection Device
- U.S. 5,735,834 Fluid Collection Device
- U.S. 5,733,721 Fluorescence image analysis
- U.S. 5,741,648 Fluorescence image analysis
- U.S. 5,824,495 text and images (text only copy) Cell fixative and preparation kit
Urocor (Oklahoma City, OK) samples are cultured in 3 dimensions, then assayed for biomarkers.
- U.S. 5,861,248 Biomarkers for detection of prostate cancer
- U.S. 5,856,112 Method for selectively inducing biomarker expression
- U.S. 5,882,864 Biomarkers and targers for diagnosis, prognosis and management of prostate disease
- WO 98/04689 Biomarkers and targets for diagnosis, prognosis and management of prostate disease
Medical Device Technologies, Inc. (Gainsville FL) working on core needle biopsy gun with replaceable collecting element. Patents:
- WO 97/49339 Biopsy Instrument

Regulations

FDA Device Advice
Guidance Document for Piston Syringes
How to Market a 501K Medical Device
FDAinfo.com FDA filings and documents by Washington Information Source Co. They also print some related newsletters.
Medical Device Agency UK some European Union info

Statistics

Nice Graphic from US Surgical
Cancer FASTATS National Center for Health Statistics (CDC)
SEER Cancer Statistics Review Excellent, reports provided by type of cancer.
"Universal Healthcare Almanac." by Linda L. Cherner. Hardcover - 466 pages. Silver & Cherner, Ltd.; ISBN: 0964502402 is a quarterly updated manual containing procedure statistics. I was unable to find a copy in any Oklahoma public library or at the Stillwater Medical Center library. It may contain FNA statistics. It certainly should contain statistics on the various cancer operations. It is available from Amazon.com for about $180.
Canadian Cancer Statistics
Cancer Mondial World wide stats World Health Org. (WHO)
World Cancer Statistics by type World Health Organization (WHO)